Tirzepatide for weight loss is a revolutionary fat loss product which has set new standards in clinical tests.
While leading research analysts have claimed that Tirzepatide has the immense capability to metabolize fat cells, the reason for this drug’s induction in the medical stream is quite different.
Simply put, Tirzepatide is a medicine that is meant to cure Type 2 Diabetes. This is a drug that is injected into the skin of the concerned patient. So, if you suffer from Type 2 Diabetes, Tirzepatide injections may help you recover faster than any other medication.
Ironically, this drug is being used to reduce body fat percentage in both men and women. This happens via Tirzepatide targeting the incretins. This is a hormone that helps metabolize your fat cells and decreases the blood sugar levels present in your blood.
The end result is hastened fat loss.
Eli Lilly & Company (the certified manufacturers of this drug) has conducted this experiment on a large number of subjects. The result derived from their research is no less than a miracle. Tirzepatide apparently melts belly fat and enables obese individuals to become lean and fit again.
PS: Tirzepatide for losing weight is still in its experimental stages.
In this article, I (LeanAndFit) shall determine whether this drug (used for treating Type 2 Diabetes) is actually worth its weight in salt or not (for helping men and women lose extra body fat).
So, here goes:
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Contents of Tirzepatide for Weight Loss Article:
1) What is Tirzepatide & What is it Used For?
2) Who Manufactures Tirzepatide?
3) How does Tirzepatide Work?
4) What is the Structure & Synthesis of this Drug?
5) Tirzepatide for Weight Loss – Is it Really Effective?
6) Does it Cause any Side Effects?
7) Insulin Spike and Weight Loss – The Dreaded Connection
8) Is Tirzepatide Your Best Bet to Lose Visceral Body Fat?
What is Tirzepatide & What is it Used For?
Tirzepatide is a drug that is used for treating patients that suffer from insulin related issues. Basically, if you suffer from Type 2 Diabetes then, this drug is injected into your system. The basic purpose of this drug is to maintain a balance between GLP-1 and GIP hormones.
What are GLP-1 & GIP Hormones?
GLP Hormone:
GLP-1 stands for Glucagon-like Peptide-1. This is a peptide secreted by the endocrinal L-cells of the intestines. The length of this peptide is 31 amino acids. Its main function is to reduce the blood glucose levels in the human body.
So, GIP-1 tends to increase the secretion of the insulin hormone. When insulin is released, the blood glucose levels tend to get stabilized.
GIP Hormone:
Commonly known as Gastric Inhibitory Peptide, this is a hormone that belongs to the secretin family. The main purpose of the GIP hormone is to emulate the secretion of insulin in the human body.
GIP hormone also restricts excess secretion of the stomach acid. When this happens, the intestinal tract of the human body (small intestines) is saved from damage caused by excessive acid secretion.
It also helps in bone re-modelling. Basically, insulin resistance is maintained at optimal levels with the aid of the Gastric Inhibitory Peptide.
Who Manufactures Tirzepatide?
Eli Lilly and Company has exclusive rights to manufacture Tirzepatide. They won the patented rights to manufacture this medicine in the year 2016. So, they have been successfully using this medicine to treat diabetics for the past 6 years.
Lilly has also started to conduct tests of Tirzepatide on obese individuals who want to lose weight fast. Basically, Lilly and Company has diversified the primary usage of this medicine. Company spokesperson states that Tirzepatide now helps non-diabetics lose weight at warp speed.
At present there is no other company in the world that has the rights to manufacture Tirzepatide. With the clinical trials in full swing and the results no less than a miracle, Lilly & Company seem to have hit the anti-obesity jackpot.
The Patent & FDA Approval:
@ Eli Lilly and Company publishes the patent for their Type 2 Diabetes drug in the year 2016.
@ This drug has received priority review voucher from the Food and Drug Administration of the United States. This was granted in the year 2021 when Tirzepatide successfully passed three clinical trial tests.
@ After the success of the SURPASS 2 trial, Lilly And Company stated that Tirzepatide was successful in helping obese individuals lose weight successfully.
@ After the successful completion of the SURMOUNT-2 trial, Lilly & Company stated that their drug was as powerful in treating diabetes (if not better) than Semaglutide (the current reigning champion).
How does Tirzepatide Work?
This drug has the ability to attract the Gastric Inhibitory Peptide receptors. Owing to this very reason, the insulin production is stabilized in the human body. This also helps in stabilizing digestive related issues.
At the same time, Tirzepatide also initiates the Glucagon-like Peptide-1. This in turn results in optimal secretion of insulin in the human body. By imitating the acts of Gastric Inhibitory Peptide receptors, this drug reduces insulin spike in men and women suffering from Type 2 Diabetes.
By binding with cAMP in the human gastrointestinal tract, Tirzepatide tends to stimulate increased insulin production. So, diabetics do not feel a sudden spike in insulin each time they consume a meal.
The lipid metabolism also gets a 25% boost a few weeks into the Tirzepatide dosage. This is owing to this drug increasing the levels of both adipokine and adiponectin in the human body.
What is the Assembly & Fusion of this Drug?
Tirzepatide comprises of thirty nine amino acids and hence, it is considered to be a polypeptide. This drug is chemically altered to improve metabolism. It is also easily accepted into the human cells.
This drug imitates the actions of Gastric Inhibitory Peptide. Owing to this very reason, insulin is secreted from the pancreas in an optimal and controlled manner. This is a boon for people suffering from Type 2 Diabetes.
The Assembly: As I have mentioned above, Tirzepatide is a chemically altered polypeptide. The aim of this alteration is to allow Tirzepatide to activate both Glucagon-like Peptide-1 and Gastric Inhibitory Peptide hormones.
When GIP combines with C20 fatty diacid (thanks to this drug), it allows optimal uptake of Tirzepatide by the human cells. This drug’s link with glutamic acid with its acetic acid profile affixing to the lysine residue sidechain, makes Tirzepatide an ideal insulin spike controller.
The Fusion: Eli Lilly and Company has exclusive rights to manufacture Tirzepatide. The chemical mutation of this drug is initiated with allyloxycarbonl fortification merging with lysine and sitting at the twentieth chain of amino acid.
This process helps synthesize the peptide thereby enabling it to emulate both GIP-1 and GLP hormones.
Tirzepatide for Weight Loss – Is it Really Effective?
Elli Lilly and Company conducted the SURPASS-2 clinical trial successfully. In this trial, Tirzepatide was injected in the skin of overweight individuals. This was done once every week.
It was found that this drug activated incretins in the human body. This reduces blood sugar levels and improves metabolism. This success led to the SURMOUNT-1 clinical trial.
SURMOUNT-1 Clinical Trial:
This trial involved two thousand five hundred and thirty nine overweight participants. Many of these fell in the obese category as well. None of the subjects suffered from diabetes (Type 1 or Type 2).
The trial lasted 16.5 months wherein a few subjects received Tirzepatide injections. The others received placebo. The dosage was divided into 5mg, 10mg and 15mg. The subjects were asked to exercise and consume a healthy diet.
Subjects that received 5mg dosage of Tirzepatide lost 35 pounds at the end of the trial period. Those that received 10mg of this drug lost 50 pounds of body weight. The 15mg dosage recipients lost a whopping 52 pounds of body weight (these are all average figures).
Ironically, the placebo group lost about 3 to 5 pounds of bodyweight. Jeff Emmick, a clinical researcher at Lilly states that Tirzepatide is the only medicine that has helped people lose 20% body weight. Although it is still in the investigational stage yet, no other fat loss drug has ever matched its might.
As the SURMOUNT-1 trial continues, the final results are expected by the end of 2023. The only setback was a handful of subjects suffering from constipation and vomiting. Apparently, this was a side effect caused by this weight loss drug.
Does it Cause any Side Effects?
@ If you suffer from the cancer that infects the perifollicular cells then, you should not consume Tirzepatide.
@ People with benign or malignant tumors of the endocrine area should also abstain from using this medicine.
@ Constipation, nausea and vomiting is a common side effect of taking this medicine. Nonetheless, only a few subjects have experienced these symptoms.
@ When Tirzepatide apes GLP-1 receptors, the medicine tends to stress the gastrointestinal tract. This is when infections are at their highest. So, pain in the abdominal area may be felt by some.
@ Some may suffer from hypoglycaemia. Burning, bloating and gas in the upper abdominal area may be experienced by a few.
@ A few people have reported to feel dizzy after taking this medicine.
Insulin Spike and Weight Loss – The Dreaded Connection
Pancreas is where your blood glucose is channelized optimally. Simply put, the food that you eat is converted into usable energy (especially carbohydrates). This conversion requires the secretion of insulin.
Pancreas and Insulin Spike:
The pancreas is responsible for secreting insulin to stabilize blood glucose levels that have increased owing to high carbohydrates in your body. Insulin is responsible for converting carbs into fat or energy. It also breaks down amino acids into muscle building protein.
While insulin helps store macros into your cells, it also inhibits the breakdown of nutrients. This includes fats, proteins and carbohydrates. It is best suggested to have a low carbohydrate diet so as to avoid fluctuations in insulin.
The food you eat is converted into glucose. This is a fuel that helps your organs, muscles and tissues function optimally. While this is a primary fuel, it is of little or no use if it cannot enter your cells. Insulin secreted by pancreas allows your cells to open and accept glucose.
If your pancreas is unable to secrete insulin in optimal levels, it forces glucose to swim in your bloodstream. This causes hyperglycemia. If your blood glucose level is higher than 250 mg/dl, you suffer from high blood glucose.
Here is how you recognize insulin spike:
@ You start to piss way more than usual.
@ The need to drink water without breaking a single bead of sweat increases dramatically.
@ You feel tired without moving a muscle.
@ Aches and pains in the body and head are a common affair.
@ Sometimes, you may feel as though your vision is compromised.
What Causes Insulin Spike?
Now that we have discussed that a spike in insulin can make you obese, let me walk you through the main causes behind this dreaded spike:
@ You may be consuming processed foods way more than necessary. This includes burgers, fries, pizza, canned foods, ready-to-eat foods etc.
@ If you drink coke, fanta, aerated drinks, coffee/tea loaded with sugar then again, you shall witness a spike in insulin.
@ Drinking alcohol tends to flood your bloodstream with a wave of glucose. This is a spike in insulin that takes a lot of time to subside. If you mix soda to your alcohol, the time taken to reduce the spike in insulin is even higher.
@ Overindulgence in jams and jellies is also a tell-tale sign of insulin spike. Fruits such as mangoes should also be avoided.
@ You lead a sedentary lifestyle and avoid exercising. This causes disruption in blood glucose levels.
How to Prevent Insulin Spikes?
@ Foods that are high in GI index need to be avoided at all costs. If you consume foods with high glycaemic index, your insulin spike shall be substantial.
@ Always maintain optimal body weight. In case you are overweight then, you need to try and reduce your body weight.
@ If you are a diabetic then, pay a visit to the doctor and ask for a meal plan. Stick with the meal plan if you want minimal insulin spikes.
@ Opt for resistance training. Instead of relying on cardio, use weight training instead. This helps you lose weight faster. It also keeps your blood sugar under control.
@ Maintain a gap of 3 to 5 hours between each meal. Doing so shall enable the insulin spike to get blunted.
@ Reduce the intake of refined sugar. This is one of the major causes behind insulin spike.
@ Increase the intake of both soluble as well as insoluble fiber. These include legumes, beans, oats, green leafy vegetables and fresh seasonal fruits.
@ Drinking 2 to 3 liters of water daily is supposed to be an ideal way to maintain optimal blood glucose levels. If you drink less than 2 liters of water daily then, extra glucose shall not be flushed out of your body.
@ Cinnamon and fenugreek are two great spices that keep your weight in check. They also help regulate glucose in your blood.
@ Eat lesser portions and reduce daily stress. Include berberine into your diet. Doing so shall reduce your overall body weight and also regulate your blood glucose levels.
Is Tirzepatide Your Best Bet to Lose Visceral Body Fat?
With the drug still under trial, it is quite possible that in a year or two, you can hope to see this medicine rocking the weight loss industry.
While semaglutide being the first FDA approved fat loss medicine, Tirzepatide could well be the ‘next big thing’ that helps lose body fat effectively. With the positive results of SURMOUNT-1 clinical trial, Tirzepatide seems to be a solution to treat obesity effectively.
While this is a medicine that has switched base from treating diabetes to weight loss, Tirzepatide is still undergoing the final phase of trial. So, till the final analysis comes from the FDA, opting for natural/herbal weight loss capsules is a wise option.
Weight loss enthusiasts should also indulge in a healthy diet plan. Also, you should opt for resistance training exercises (at least thrice a week). If you maintain a healthy lifestyle, losing weight naturally is not at all a daunting task.